Very severely depressed patients.

Antidepressants only benefit some A new research published in PLoS Medication suggests that antidepressants just benefit some, very severely depressed patients. Nevertheless some studies have suggested that these drugs usually do not help nearly all depressed people progress by quite definitely . Irving Kirsch, from the University of Hull, and his colleagues, studied this question in closer detail, looking at whether a patient’s response to antidepressant therapy depends upon how badly depressed they are to begin with. . By including data from unpublished as well as published trials, the researchers set out to avoid bias that may come from non-publication of disappointing results.

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