During islet transplantation, the pancreatic cell complexes are injected into a large vein that feeds into the liver, where they lodge. Cells within the islets, called beta cells, then produce insulin. The person receiving the transplant must consider anti-rejection medications. Dr. Unger stated that after 2 yrs, 87 % of recipients must resume taking insulin, a problem that has led clinicians to investigate if the anti-rejection drugs are at fault, or if various other mechanism is at work. In the current study, UT Southwestern researchers tested the hypothesis that fat in the liver may be killing the beta cells. The researchers also theorized that the insulin that all islet created might stimulate fat manufacture around itself, adding to the nagging problem.These findings appear on-line in the Journal of the American Geriatrics Culture currently. Previous research about offspring and siblings of centenarians possess documented that remarkable longevity runs strongly in families. Studies of the offspring of centenarians showed that their mortality is 120 % less than other people of their birth cohort and they also have markedly lower prevalence rates and delayed onsets of coronary disease, hypertension, and diabetes mellitus. Because personality traits have been shown to have considerable heritable components, the researchers hypothesized that certain personality features could be vital that you the healthy aging seen in the offspring of centenarians.